EpCAM and solid tumour fractionation

Tumour radiobiology beyond fractionation

Historically it has been shown repeatedly that single high doses of radiation do not allow a therapeutic differential between tumor and critical normal tissues but dose fractionation does. The purpose of conventional dose fractionation is to increase dose to the tumor while preserving normal tissue function. Tumors are generally irradiated with 2Gy dose per fraction delivered daily to a more or...

Solid Tumour Section

Solid Tumour Section

HMGA2 (high mobility group AT-hook 2) Location: 12q15 DNA/RNA The gene consists of 5 exons that span approximately 160 kb of genomic DNA in the centromere-to-telomere orientation. The first three exons are separated from the last two exons by a particularly large intron (about 112 kb). The corresponding transcript is approximately 4,1 kb (referred to as 'wildtype' or 'isoform a' transcript of H...

Solid Tumour Section

FLC shows immunohistochemical features of both hepatocytic and biliary differentiation and is most likely derived from a bipotential cell. A recent study examining 26 cases of FLC and 62 cases of classical HCC by immunohistochemistry showed that both tumor types stained uniformly positively with HepPar1 and most showed a canalicular staining pattern for pCEA confirming hepatocytic differentiati...

Solid Tumour Section

Eastern Asia and sub-Saharan Africa are the most prevalent regions. Hepatitis B virus (HBV) is a major risk factor. In some geographic areas (e.g. Asia, Southern Africa), aflatoxin B1 (AFB1) is also considered to be a significant etiologic factor. Exposure to dietary AFB1 and chronic HBV infection are synergistic risk factors in chinese areas of high-HCC incidence. HCC is also a late complicati...